Almost every existing operating system supports IPv6 and enables it by default nowadays. Some system admins still like to disable IPv6, because they think they would not deploy IPv6 in the near future. However, disabling IPv6 can be against the software vendor recommendation or experience the unexpected bug.
For example, Microsoft do not recommend disabling IPv6 in Windows. See “IPv6 for Microsoft Windows FAQ” and “How to disable IPv6 or its components in Windows”.
Recently, VMware ESXi 6.0.x has a known issue when IPv6 is disabled. See “Provisioning the TCP/IP stack does not work when IPv6 support is disabled on the host (2146023)”
To avoid the unexpected issue, we should leave IPv6 enabled (the default).
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