On my work PC, I use OneDrive for Business instead of OneDrive. By default Windows 10 includes an OneDrive shortcut in File Explorer side panel.
Change the following registry key to remove it.
- {HKEY_CLASSES_ROOT\CLSID\{018D5C66-4533-4307-9B53-224DE2ED1FE6}
- In the subkey System.IsPinnedToNameSpaceTree change the DWORD from 1 to 0
- No reboot required.
Source: Microsoft TechNet Forums
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